Intramacrophage survival of uropathogenic Escherichia coli: differences between diverse clinical isolates and between mouse and human macrophages
Uropathogenic E. coli (UPEC) are the primary cause of urinary tract infections. Recent
studies have demonstrated that UPEC can invade and replicate within epithelial cells,
suggesting that this bacterial pathogen may occupy an intracellular niche within the host.
Given that many intracellular pathogens target macrophages, we assessed the interactions
between UPEC and macrophages. Colonization of the mouse bladder by UPEC strain
CFT073 resulted in increased expression of myeloid-restricted genes, consistent with the …
studies have demonstrated that UPEC can invade and replicate within epithelial cells,
suggesting that this bacterial pathogen may occupy an intracellular niche within the host.
Given that many intracellular pathogens target macrophages, we assessed the interactions
between UPEC and macrophages. Colonization of the mouse bladder by UPEC strain
CFT073 resulted in increased expression of myeloid-restricted genes, consistent with the …