Down-regulation of Z39Ig on macrophages by IFN-γ in patients with chronic HBV infection
S Guo, C Yang, F Mei, S Wu, N Luo, L Fei, Y Chen… - Clinical …, 2010 - Elsevier
Co-inhibitory signals from the B7 superfamily have been demonstrated to induce T cell
dysfunction in chronic HBV infection (CHB). However, the expression and function of Z39Ig,
a new inhibitor of the B7 superfamily, is still unclear in CHB. Here immunohistochemical
staining showed that Z39Ig was restricted to macrophages and that its level was decreased
significantly in CHB patients compared to healthy controls. Moreover, reduced Z39Ig
expression was positively correlated with plasma HBV load but was inversely related to …
dysfunction in chronic HBV infection (CHB). However, the expression and function of Z39Ig,
a new inhibitor of the B7 superfamily, is still unclear in CHB. Here immunohistochemical
staining showed that Z39Ig was restricted to macrophages and that its level was decreased
significantly in CHB patients compared to healthy controls. Moreover, reduced Z39Ig
expression was positively correlated with plasma HBV load but was inversely related to …