[HTML][HTML] Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer
AJ Wilson, DS Byun, N Popova, LB Murray… - Journal of Biological …, 2006 - ASBMB
Inhibitors of histone deacetylases (HDACs) induce growth arrest, differentiation, and
apoptosis of colon cancer cell lines in vitro and have demonstrated anti-cancer efficacy in
clinical trials. Whereas a role for HDAC1 and-2 in mediating components of the HDAC
inhibitor response has been reported, the role of HDAC3 is unknown. Here we demonstrate
increased protein expression of HDAC3 in human colon tumors and in duodenal adenomas
from Apc1638 N/+ mice. HDAC3 was also maximally expressed in proliferating crypt cells in …
apoptosis of colon cancer cell lines in vitro and have demonstrated anti-cancer efficacy in
clinical trials. Whereas a role for HDAC1 and-2 in mediating components of the HDAC
inhibitor response has been reported, the role of HDAC3 is unknown. Here we demonstrate
increased protein expression of HDAC3 in human colon tumors and in duodenal adenomas
from Apc1638 N/+ mice. HDAC3 was also maximally expressed in proliferating crypt cells in …