Proline 326 in the C terminus of murine CX3CR1 prevents G-protein and phosphatidylinositol 3-kinase-dependent stimulation of Akt and extracellular signal-regulated …
CN Davis, JK Harrison - The Journal of pharmacology and experimental …, 2006 - Elsevier
Naturally occurring single nucleotide polymorphisms have been identified in human
CX3CR1, the chemokine receptor for fractalkine (FKN/CX3CL1). Individuals carrying the
I249/M280 variant of CX3CR1 have a lower risk of cardiovascular disease compared with
those homozygous for the common variant (V249/T280). The precise molecular basis for this
phenotype is unclear, although differences in FKN binding, adhesive properties, and
signaling efficiency between the CX3CR1 variants have been reported. FKN binding to …
CX3CR1, the chemokine receptor for fractalkine (FKN/CX3CL1). Individuals carrying the
I249/M280 variant of CX3CR1 have a lower risk of cardiovascular disease compared with
those homozygous for the common variant (V249/T280). The precise molecular basis for this
phenotype is unclear, although differences in FKN binding, adhesive properties, and
signaling efficiency between the CX3CR1 variants have been reported. FKN binding to …