[HTML][HTML] CCL5-CCR5-mediated apoptosis in T cells: Requirement for glycosaminoglycan binding and CCL5 aggregation
TT Murooka, MM Wong, R Rahbar… - Journal of biological …, 2006 - ASBMB
CCL5 (RANTES (regulated on activation normal T cell expressed and secreted)) and its
cognate receptor, CCR5, have been implicated in T cell activation. CCL5 binding to
glycosaminoglycans (GAGs) on the cell surface or in extracellular matrix sequesters CCL5,
thereby immobilizing CCL5 to provide the directional signal. In two CCR5-expressing
human T cell lines, PM1. CCR5 and MOLT4. CCR5, and in human peripheral blood-derived
T cells, micromolar concentrations of CCL5 induce apoptosis. CCL5-induced cell death …
cognate receptor, CCR5, have been implicated in T cell activation. CCL5 binding to
glycosaminoglycans (GAGs) on the cell surface or in extracellular matrix sequesters CCL5,
thereby immobilizing CCL5 to provide the directional signal. In two CCR5-expressing
human T cell lines, PM1. CCR5 and MOLT4. CCR5, and in human peripheral blood-derived
T cells, micromolar concentrations of CCL5 induce apoptosis. CCL5-induced cell death …
