miR-155 mediates suppressive effect of progesterone on TLR3, TLR4-triggered immune response
Y Sun, J Cai, F Ma, P Lü, H Huang, J Zhou - Immunology letters, 2012 - Elsevier
It has been demonstrated that progesterone has immune suppressive properties and can
inhibit Toll-like receptor 4 (TLR4)-triggered immune response. Multiple microRNAs are
induced in innate immune cells, among them miR-155, miR-146a and miR-21 are
particularly ubiquitous. In this study, we investigated the potential roles of miR-155 in
progesterone-mediated regulation of innate immune responses. We found that progesterone
pre-treatment suppressed LPS-and poly (I: C)-induced miR-155 expression in …
inhibit Toll-like receptor 4 (TLR4)-triggered immune response. Multiple microRNAs are
induced in innate immune cells, among them miR-155, miR-146a and miR-21 are
particularly ubiquitous. In this study, we investigated the potential roles of miR-155 in
progesterone-mediated regulation of innate immune responses. We found that progesterone
pre-treatment suppressed LPS-and poly (I: C)-induced miR-155 expression in …