TGFβ can inhibit the in vitro proliferation, survival, and differentiation of B cell progenitors,
mature B lymphocytes, and plasma cells. Unexpectedly, TGFβ1−/− mice were found to have
age-dependent reductions in the bone marrow (BM) B cell progenitor and immature B cell
compartments. Normal (C57BL/6) BM B lineage cell responses to TGFβ1 in IL7 cultures
showed differential outcomes of B cell progenitor subsets. Low doses of TGFβ1 (1.6 pM)
reduced the pro-B-enriched population at every timepoint of a week-long culture. In contrast …

ABSTRACT OF DISSERTATION GRADUATE SCHOOL. UN IVER SITY OF ALABAMA AT B
IR M IN GHAM Degree Ph. D. Program M icrobiology_________________________…
Name of Candidate Denise A. Kaminski__________________________… Committee
Chair Peter D. Burrows___________________________… Title Differential Regulation of
Mouse B Cell Development bv TGFBl______________ TGFP can inhibit the in vitro
proliferation, survival, and differentiation of B cell progenitors, mature B lymphocytes, and …