Induced murine models of systemic lupus erythematosus
Systemic lupus erythematosus: methods and protocols, 2014•Springer
Induced mouse models of systemic lupus erythematosus (SLE) have been developed to
complement the spontaneous models. This chapter describes the methods used in the
pristane-induced model and the chronic graft-versus-host disease (cGVHD) model, both of
which have been extensively used. We will also outline the specific mechanisms of systemic
autoimmunity that can be best characterized using each of these models.
complement the spontaneous models. This chapter describes the methods used in the
pristane-induced model and the chronic graft-versus-host disease (cGVHD) model, both of
which have been extensively used. We will also outline the specific mechanisms of systemic
autoimmunity that can be best characterized using each of these models.
Abstract
Induced mouse models of systemic lupus erythematosus (SLE) have been developed to complement the spontaneous models. This chapter describes the methods used in the pristane-induced model and the chronic graft-versus-host disease (cGVHD) model, both of which have been extensively used. We will also outline the specific mechanisms of systemic autoimmunity that can be best characterized using each of these models.
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