Transdermal application of myelin peptides in multiple sclerosis treatment
A Walczak, M Siger, A Ciach, M Szczepanik… - JAMA …, 2013 - jamanetwork.com
Importance Demonstration of efficacious antigen-specific therapy in multiple sclerosis.
Objective To assess the safety and efficacy of transdermally applied myelin peptides in
patients with relapsing-remitting multiple sclerosis. Design One-year double-blind, placebo-
controlled cohort study. Setting Referral center. Participants Thirty outpatients aged 18 to 55
years with relapsing-remitting multiple sclerosis. Intervention Skin patch with a mixture of 3
myelin peptides, MBP85-99, MOG35-55, and PLP139-155. Main Outcomes and Measures …
Objective To assess the safety and efficacy of transdermally applied myelin peptides in
patients with relapsing-remitting multiple sclerosis. Design One-year double-blind, placebo-
controlled cohort study. Setting Referral center. Participants Thirty outpatients aged 18 to 55
years with relapsing-remitting multiple sclerosis. Intervention Skin patch with a mixture of 3
myelin peptides, MBP85-99, MOG35-55, and PLP139-155. Main Outcomes and Measures …