Expression of two T cell receptor α chains: dual receptor T cells
E Padovan, G Casorati, P Dellabona, S Meyer… - Science, 1993 - science.org
Science, 1993•science.org
Although many T cells carry two in-frame Vα rearrangements, the products of both Vα
rearrangements have never been shown simultaneously on the surface of normal cells. With
the use of monoclonal antibodies to Vα2, Vα12, and Vα24, up to one-third of mature T cells
expressed two Vα chains as part of two functional and independent T cell receptors (TCRs).
Thus, the" one cell, one receptor" rule does not apply to a large subset of αβ T cells. Cells
that belong to this dual TCR subset may be specific for a broader range of antigens than …
rearrangements have never been shown simultaneously on the surface of normal cells. With
the use of monoclonal antibodies to Vα2, Vα12, and Vα24, up to one-third of mature T cells
expressed two Vα chains as part of two functional and independent T cell receptors (TCRs).
Thus, the" one cell, one receptor" rule does not apply to a large subset of αβ T cells. Cells
that belong to this dual TCR subset may be specific for a broader range of antigens than …
Although many T cells carry two in-frame Vα rearrangements, the products of both Vα rearrangements have never been shown simultaneously on the surface of normal cells. With the use of monoclonal antibodies to Vα2, Vα12, and Vα24, up to one-third of mature T cells expressed two Vα chains as part of two functional and independent T cell receptors (TCRs). Thus, the "one cell, one receptor" rule does not apply to a large subset of αβ T cells. Cells that belong to this dual TCR subset may be specific for a broader range of antigens than cells with a single receptor, which may be important for autoimmunity and alloreactivity.
AAAS