T-cell receptor Vα and Vβ gene use by infiltrating T cells in labial glands of patients with Sjögren's syndrome
Y Ohyama, S Nakamura, G Matsuzaki… - Oral Surgery, Oral …, 1995 - Elsevier
Sjögren's syndrome is an autoimmune disease affecting the exocrine glands; it is thought to
result from T-cell-mediated damage. In the labial glands of 20 patients with Sjögren's
syndrome, infiltrating T cells were immunohistochemically characterized, and T-cell receptor
(TCR) gene expression was examined with a method based on polymerase chain reaction.
Most of these lymphocytes expressed CD3, CD4, CD45RO, and TCRαβ, whereas less than
5% of them expressed CD25 and CD69. The TCR Vα and Vβ genes expressed in peripheral …
result from T-cell-mediated damage. In the labial glands of 20 patients with Sjögren's
syndrome, infiltrating T cells were immunohistochemically characterized, and T-cell receptor
(TCR) gene expression was examined with a method based on polymerase chain reaction.
Most of these lymphocytes expressed CD3, CD4, CD45RO, and TCRαβ, whereas less than
5% of them expressed CD25 and CD69. The TCR Vα and Vβ genes expressed in peripheral …