Seeing through VEGF: innate and adaptive immunity in pathological angiogenesis in the eye

A Sene, D Chin-Yee, RS Apte - Trends in molecular medicine, 2015 - cell.com
A Sene, D Chin-Yee, RS Apte
Trends in molecular medicine, 2015cell.com
The central role of vascular endothelial growth factor (VEGF) signaling in regulating normal
vascular development and pathological angiogenesis has been documented in multiple
studies. Ocular anti-VEGF therapy is highly effective for treating a subset of patients with
blinding eye disorders such as diabetic retinopathy and neovascular age-related macular
degeneration (AMD). However, chronic VEGF suppression can lead to adverse effects
associated with poor visual outcomes due to the loss of prosurvival and neurotrophic …
The central role of vascular endothelial growth factor (VEGF) signaling in regulating normal vascular development and pathological angiogenesis has been documented in multiple studies. Ocular anti-VEGF therapy is highly effective for treating a subset of patients with blinding eye disorders such as diabetic retinopathy and neovascular age-related macular degeneration (AMD). However, chronic VEGF suppression can lead to adverse effects associated with poor visual outcomes due to the loss of prosurvival and neurotrophic capacities of VEGF. In this review, we discuss emerging evidence for immune-related mechanisms that regulate ocular angiogenesis in a VEGF-independent manner. These novel molecular and cellular pathways may provide potential therapeutic avenues for a multitarget strategy, preserving the neuroprotective functions of VEGF in those patients whose disease is unresponsive to VEGF neutralization.
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