[HTML][HTML] Exosomes from HIV-1-infected cells stimulate production of pro-inflammatory cytokines through trans-activating response (TAR) RNA
GC Sampey, M Saifuddin, A Schwab, R Barclay… - Journal of Biological …, 2016 - ASBMB
HIV-1 infection results in a chronic illness because long-term highly active antiretroviral
therapy can lower viral titers to an undetectable level. However, discontinuation of therapy
rapidly increases virus burden. Moreover, patients under highly active antiretroviral therapy
frequently develop various metabolic disorders, neurocognitive abnormalities, and
cardiovascular diseases. We have previously shown that exosomes containing trans-
activating response (TAR) element RNA enhance susceptibility of undifferentiated naive …
therapy can lower viral titers to an undetectable level. However, discontinuation of therapy
rapidly increases virus burden. Moreover, patients under highly active antiretroviral therapy
frequently develop various metabolic disorders, neurocognitive abnormalities, and
cardiovascular diseases. We have previously shown that exosomes containing trans-
activating response (TAR) element RNA enhance susceptibility of undifferentiated naive …