[CITATION][C] TNF inhibitors directly target Th17 cells via attenuation of autonomous TNF/TNFR2 signalling in psoriasis
T Shiga, K Sato, S Kataoka, S Sano - Journal of Dermatological …, 2015 - jdsjournal.com
Psoriasis is a chronic inflammatory skin disease characterized by increased proliferation
and altered differentiation of the ep idermis and inflammatory cell infiltrates in the dermis. A
number of recent studies have demonstrated that the IL-23/Th17 axis is essential for the
pathogenesis of psoriasis [1]. The therapeutic efficacy of antibodies to IL-23, including those
t argeting either the p40 or the p19 subunit, has confirmed the r ole of IL-23, which is a driver
for Th17 cells to mature and p roliferate[2]. More recently, direct targeting of the IL-17 …
and altered differentiation of the ep idermis and inflammatory cell infiltrates in the dermis. A
number of recent studies have demonstrated that the IL-23/Th17 axis is essential for the
pathogenesis of psoriasis [1]. The therapeutic efficacy of antibodies to IL-23, including those
t argeting either the p40 or the p19 subunit, has confirmed the r ole of IL-23, which is a driver
for Th17 cells to mature and p roliferate[2]. More recently, direct targeting of the IL-17 …