[HTML][HTML] Estrogen regulation of adiposity and fuel partitioning: evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways
MD Tara, SC Souza, M Aronovitz, MS Obin… - Journal of Biological …, 2005 - ASBMB
Menopause is associated with increased adiposity and greater risk of metabolic disease. In
the ovariectomized (OVX) rodent model of menopause, increased adiposity is prevented by
estrogen (E2) replacement, reflecting both anorexigenic and potentially metabolic actions of
E2. To elucidate metabolic and molecular mechanisms by which E2 regulates fat storage
and fat mobilization independently of reduced energy intake, C57 BL/6 mice were
ovariectomized, randomized to estrogen (OVX-E2) or control pellet implants (OVX-C), and …
the ovariectomized (OVX) rodent model of menopause, increased adiposity is prevented by
estrogen (E2) replacement, reflecting both anorexigenic and potentially metabolic actions of
E2. To elucidate metabolic and molecular mechanisms by which E2 regulates fat storage
and fat mobilization independently of reduced energy intake, C57 BL/6 mice were
ovariectomized, randomized to estrogen (OVX-E2) or control pellet implants (OVX-C), and …