Daily dosing with flutamide or Casodex exerts maximal antiandrogenic activity
S Luo, C Martel, C Chen, C Labrie, B Cands, SM Singh… - Urology, 1997 - Elsevier
OBJECTIVES: Because the large increase in luteinizing hormone secretion induced by
flutamide in the intact rat is not found in men, we have used castrated rats and mice
supplemented with androstenedione (4-dione) instead of intact animals to measure the
activity of the pure antiandrogens flutamide and Casodex. METHODS: We first compared the
effect of different schedules of administration of various doses of the two antiandrogens on
prostate and seminal vesicle weights in the castrated rat and mice models. RESULTS: For …
flutamide in the intact rat is not found in men, we have used castrated rats and mice
supplemented with androstenedione (4-dione) instead of intact animals to measure the
activity of the pure antiandrogens flutamide and Casodex. METHODS: We first compared the
effect of different schedules of administration of various doses of the two antiandrogens on
prostate and seminal vesicle weights in the castrated rat and mice models. RESULTS: For …