Cyclooxygenase-2 inhibition and hypoxia-induced pulmonary hypertension: effects on pulmonary vascular remodeling and contractility
LE Fredenburgh, J Ma, MA Perrella - Trends in cardiovascular medicine, 2009 - Elsevier
Pulmonary arterial hypertension (PAH) is a significant disease process characterized by
elevated pulmonary vascular resistance leading to increased right ventricular afterload and
ultimately progressing to right ventricular dysfunction and often death. Irreversible
remodeling of the pulmonary vasculature is the hallmark of pulmonary hypertension and
frequently leads to progressive functional decline in patients with PAH despite treatment with
currently available therapies. Metabolites of the arachidonic acid cascade play an important …
elevated pulmonary vascular resistance leading to increased right ventricular afterload and
ultimately progressing to right ventricular dysfunction and often death. Irreversible
remodeling of the pulmonary vasculature is the hallmark of pulmonary hypertension and
frequently leads to progressive functional decline in patients with PAH despite treatment with
currently available therapies. Metabolites of the arachidonic acid cascade play an important …