Changes in interleukin-1beta in serum and bronchoalveolar lavage fluid in the patient with acute respiratory distress syndrome
XR Luo, WL Wu, L Wang, XQ Ye… - … wei Zhong Bing ji jiu yi …, 2003 - europepmc.org
XR Luo, WL Wu, L Wang, XQ Ye, D Zhang
Zhongguo wei Zhong Bing ji jiu yi xue= Chinese Critical Care Medicine …, 2003•europepmc.orgObjective To study the role of interleukin-1beta (IL-1beta) in the pathogenesis of acute
respiratory distress syndrome (ARDS). Methods The bronchoalveolar lavage fluid (BALF)
and serum in 13 patients with ARDS and 9 healthy controls were collected. The contents of
IL-1beta were measured by enzyme-linked immunoadsorbent assay (ELISA). Results The
levels of IL-1beta in BALF [(144.67+/-80.79) ng/L] and serum [(45.71+/-7.09) ng/L] in patients
with ARDS were significantly higher than those in the control groups [(20.39+/-1.87) ng/L, P …
respiratory distress syndrome (ARDS). Methods The bronchoalveolar lavage fluid (BALF)
and serum in 13 patients with ARDS and 9 healthy controls were collected. The contents of
IL-1beta were measured by enzyme-linked immunoadsorbent assay (ELISA). Results The
levels of IL-1beta in BALF [(144.67+/-80.79) ng/L] and serum [(45.71+/-7.09) ng/L] in patients
with ARDS were significantly higher than those in the control groups [(20.39+/-1.87) ng/L, P …
Objective
To study the role of interleukin-1beta (IL-1beta) in the pathogenesis of acute respiratory distress syndrome (ARDS).
Methods
The bronchoalveolar lavage fluid (BALF) and serum in 13 patients with ARDS and 9 healthy controls were collected. The contents of IL-1beta were measured by enzyme-linked immunoadsorbent assay (ELISA).
Results
The levels of IL-1beta in BALF [(144.67+/-80.79) ng/L] and serum [(45.71+/-7.09) ng/L] in patients with ARDS were significantly higher than those in the control groups [(20.39+/-1.87) ng/L, P= 0.000;(35.06+/-5.46) ng/L, P= 0.001, respectively], and the levels of IL-1beta in BALF were also significantly higher than those of the serum in the patients with ARDS (P= 0.000).
Conclusion
The results indicate that IL-1beta is involved in the pathogenesis of ARDS. Early determination of IL-1beta level in BALF may be more valuable in the evaluation of disease process of ARDS.
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