Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult …
DR McCulloch, C Le Goff, S Bhatt, LJ Dixon… - Gene Expression …, 2009 - Elsevier
The secreted metalloprotease ADAMTS5 is implicated in destruction of the cartilage
proteoglycan aggrecan in arthritis, but its physiological functions are unknown. Its
expression profile during embryogenesis and in adult tissues is therefore of considerable
interest. β-Galactosidase (β-gal) histochemistry, enabled by a LacZ cassette inserted in the
Adamts5 locus, and validated by in situ hybridization with an Adamts5 cRNA probe and
ADAMTS5 immunohistochemistry, was used to profile Adamts5 expression during mouse …
proteoglycan aggrecan in arthritis, but its physiological functions are unknown. Its
expression profile during embryogenesis and in adult tissues is therefore of considerable
interest. β-Galactosidase (β-gal) histochemistry, enabled by a LacZ cassette inserted in the
Adamts5 locus, and validated by in situ hybridization with an Adamts5 cRNA probe and
ADAMTS5 immunohistochemistry, was used to profile Adamts5 expression during mouse …