[HTML][HTML] A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms

SS Apte - Journal of Biological Chemistry, 2009 - ASBMB
Together with seven ADAMTS-like proteins, the 19 mammalian ADAMTS proteases
constitute a superfamily. ADAMTS proteases are secreted zinc metalloproteases whose
hallmark is an ancillary domain containing one or more thrombospondin type 1 repeats.
ADAMTS-like proteins resemble ADAMTS ancillary domains and lack proteolytic activity.
Vertebrate expansion of the superfamily reflects emergence of new substrates, duplication of
proteolytic activities in new contexts, and cooperative functions of the duplicated genes …