Previous studies have explicitly shown that small nerve fibers are affected in Fabry disease
which is assumed to cause the severe neuropathic pain that patients may have from
childhood on. Neuropathic pain and small fiber neuropathy characteristics have therefore
been considered as appropriate study endpoints in studies on the efficacy of enzyme
replacement therapy. However, the relationship between small fiber neuropathy
characteristics and pain, as well as the course of small fiber neuropathy in Fabry disease is …