Amniotic fluid infection, inflammation, and colonization in preterm labor with intact membranes
Objective The purpose of this study was to compare intraamniotic inflammation vs microbial
invasion of the amniotic cavity (MIAC) as predictors of adverse outcome in preterm labor with
intact membranes. Study Design Interleukin-6 (IL-6) was measured in prospectively
collected amniotic fluid from 305 women with preterm labor. MIAC was defined by amniotic
fluid culture and/or detection of microbial 16S ribosomal DNA. Cases were categorized into
5 groups: infection (MIAC; IL-6,≥ 11.3 ng/mL); severe inflammation (no MIAC; IL-6,≥ 11.3 …
invasion of the amniotic cavity (MIAC) as predictors of adverse outcome in preterm labor with
intact membranes. Study Design Interleukin-6 (IL-6) was measured in prospectively
collected amniotic fluid from 305 women with preterm labor. MIAC was defined by amniotic
fluid culture and/or detection of microbial 16S ribosomal DNA. Cases were categorized into
5 groups: infection (MIAC; IL-6,≥ 11.3 ng/mL); severe inflammation (no MIAC; IL-6,≥ 11.3 …