Signaling via the type I IL-1 and TNF receptors is necessary for bacterially induced preterm labor in a murine model
E Hirsch, Y Filipovich, M Mahendroo - American journal of obstetrics and …, 2006 - Elsevier
OBJECTIVE: We have shown previously that interleukin 1 (IL-1) signaling is not necessary
for bacterially induced preterm delivery in mice. We now test whether combined signaling of
IL-1 and tumor necrosis factor (TNF) is critical for this process. STUDY DESIGN: Female
mice lacking the type I receptors for IL-1 and TNF (Il1r1/Tnfrsf1a double-knockouts) and
normal controls underwent intrauterine inoculation with killed Escherichia coli bacteria on
day 14.5 of a 19-to 20-day gestation. Preterm delivery rates within 48 hours were recorded …
for bacterially induced preterm delivery in mice. We now test whether combined signaling of
IL-1 and tumor necrosis factor (TNF) is critical for this process. STUDY DESIGN: Female
mice lacking the type I receptors for IL-1 and TNF (Il1r1/Tnfrsf1a double-knockouts) and
normal controls underwent intrauterine inoculation with killed Escherichia coli bacteria on
day 14.5 of a 19-to 20-day gestation. Preterm delivery rates within 48 hours were recorded …