Induction of high mobility group box-1 in dorsal root ganglion contributes to pain hypersensitivity after peripheral nerve injury
M Shibasaki, M Sasaki, M Miura, K Mizukoshi, H Ueno… - Pain, 2010 - Elsevier
Pro-inflammatory cytokine high mobility group box-1 (HMGB-1) is involved in inflammation in
the central nervous system, but less is known about its biological effects in the peripheral
nervous system. In the present study, the role of HMGB-1 in the primary afferent nerve was
investigated in the context of the pathophysiology of peripheral nerve injury-induced pain
hypersensitivity. Real-time PCR confirmed an increase in HMGB-1 mRNA expression in the
dorsal root ganglion (DRG) and spinal nerve at 1day after spinal nerve ligation (SNL) …
the central nervous system, but less is known about its biological effects in the peripheral
nervous system. In the present study, the role of HMGB-1 in the primary afferent nerve was
investigated in the context of the pathophysiology of peripheral nerve injury-induced pain
hypersensitivity. Real-time PCR confirmed an increase in HMGB-1 mRNA expression in the
dorsal root ganglion (DRG) and spinal nerve at 1day after spinal nerve ligation (SNL) …