[HTML][HTML] A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity
The activation of spinal cord glial cells has been implicated in the development of
neuropathic pain upon peripheral nerve injury. The molecular mechanisms underlying glial
cell activation, however, have not been clearly elucidated. In this study, we found that
damaged sensory neurons induce the expression of tumor necrosis factor-α, interleukin-1β,
interleukin-6, and inducible nitric-oxide synthase genes in spinal cord glial cells, which is
implicated in the development of neuropathic pain. Studies using primary glial cells isolated …
neuropathic pain upon peripheral nerve injury. The molecular mechanisms underlying glial
cell activation, however, have not been clearly elucidated. In this study, we found that
damaged sensory neurons induce the expression of tumor necrosis factor-α, interleukin-1β,
interleukin-6, and inducible nitric-oxide synthase genes in spinal cord glial cells, which is
implicated in the development of neuropathic pain. Studies using primary glial cells isolated …
