IL-17 induces hyperalgesia via TNF-dependent neutrophil infiltration
KE McNamee, S Alzabin, JP Hughes, P Anand… - PAIN®, 2011 - Elsevier
Interleukin-17 (IL-17) and tumour necrosis factor-α (TNF) are critical in the pathogenesis of
arthritis but their relationship during inflammatory pain has received limited attention. We
aimed to establish whether IL-17 can induce hyperalgesia in acute conditions, and
investigated the role of TNF in mediating the pain response. Hyperalgesia was elicited in
C57BL/6 mice by injection of recombinant IL-17, TNF or vehicle into the plantar tissue.
Elevated pain was measured by the Hargreaves test for thermal hyperalgesia and Linton …
arthritis but their relationship during inflammatory pain has received limited attention. We
aimed to establish whether IL-17 can induce hyperalgesia in acute conditions, and
investigated the role of TNF in mediating the pain response. Hyperalgesia was elicited in
C57BL/6 mice by injection of recombinant IL-17, TNF or vehicle into the plantar tissue.
Elevated pain was measured by the Hargreaves test for thermal hyperalgesia and Linton …