Recent works in the area of stroke and brain ischemia has demonstrated the significance of
the inflammatory response accompanying necrotic brain injury. Acutely, this response
appears to contribute to ischemic pathology, and anti-inflammatory strategies have become
popular. This chapter will discuss the current knowledge of the contribution of systemic and
local inflammation in experimental stroke. It will review the role of specific cell types
including leukocytes, endothelium, glia, microglia, the extracellular matrix and neurons …