[HTML][HTML] Regulation of the Na+/Ca2+ exchanger by pyridine nucleotide redox potential in ventricular myocytes
T Liu, B O'Rourke - Journal of Biological Chemistry, 2013 - ASBMB
The cardiac Na+/Ca 2+ exchanger (NCX) is the major Ca 2+ efflux pathway on the
sarcolemma, counterbalancing Ca 2+ influx via L-type Ca 2+ current during excitation-
contraction coupling. Altered NCX activity modulates the sarcoplastic reticulum Ca 2+ load
and can contribute to abnormal Ca 2+ handling and arrhythmias. NADH/NAD+ is the main
redox couple controlling mitochondrial energy production, glycolysis, and other redox
reactions. Here, we tested whether cytosolic NADH/NAD+ redox potential regulates NCX …
sarcolemma, counterbalancing Ca 2+ influx via L-type Ca 2+ current during excitation-
contraction coupling. Altered NCX activity modulates the sarcoplastic reticulum Ca 2+ load
and can contribute to abnormal Ca 2+ handling and arrhythmias. NADH/NAD+ is the main
redox couple controlling mitochondrial energy production, glycolysis, and other redox
reactions. Here, we tested whether cytosolic NADH/NAD+ redox potential regulates NCX …