Glomerular lipid deposition and proteinuria in a patient with familial dysbetalipoproteinaemia

KR Balson, JF Niall, JD Best - Journal of internal medicine, 1996 - Wiley Online Library
KR Balson, JF Niall, JD Best
Journal of internal medicine, 1996Wiley Online Library
This report describes a male patient who was found to have proteinuria at age 31. Renal
biopsy showed glomerular hypercellularity with enlarged, lipid‐filled endocapillary cells. On
subsequent lipid analysis there was elevation of cholesterol and triglyceride, with
apolipoprotein E genotype E2/E2. The clinical course was complicated by pancreatitis and
onset of diabetes. After treatment with gemfibrozil and some improvement of the lipid profile,
a second renal biopsy showed marked reduction of the glomerular foam cells, despite an …
This report describes a male patient who was found to have proteinuria at age 31. Renal biopsy showed glomerular hypercellularity with enlarged, lipid‐filled endocapillary cells. On subsequent lipid analysis there was elevation of cholesterol and triglyceride, with apolipoprotein E genotype E2/E2. The clinical course was complicated by pancreatitis and onset of diabetes. After treatment with gemfibrozil and some improvement of the lipid profile, a second renal biopsy showed marked reduction of the glomerular foam cells, despite an increased level of proteinuria. This case emphasizes the potential role that lipid abnormalities may play in renal dysfunction.
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