Distribution of type IV collagen in the cochlea in Alport syndrome
Objective To determine the distribution of α1, α3, and α5 chains of type IV collagen in the
cochlea in Alport syndrome. Design Case-control study. Patients Two patients with
sensorineural hearing loss due to Alport syndrome. Both patients had known mutations in
theCOL4A5gene. Main Outcome Measures Immunostaining was used to study the
distribution of type IV collagen (α1, α3, and α5 chains) within the cochlea. Immunostaining
was also performed in the cochlear tissues of an unaffected individual used as a control …
cochlea in Alport syndrome. Design Case-control study. Patients Two patients with
sensorineural hearing loss due to Alport syndrome. Both patients had known mutations in
theCOL4A5gene. Main Outcome Measures Immunostaining was used to study the
distribution of type IV collagen (α1, α3, and α5 chains) within the cochlea. Immunostaining
was also performed in the cochlear tissues of an unaffected individual used as a control …