[HTML][HTML] Expression of human hormone-sensitive lipase in white adipose tissue of transgenic mice increases lipase activity but does not enhance in vitro lipolysis
S Lucas, G Tavernier, C Tiraby, A Mairal… - Journal of lipid …, 2003 - ASBMB
Hormone-sensitive lipase (H1111117) catalyzes the hydrolysis of acylglycerols and
cholesteryl esters (CEs). The enzyme is highly expressed in adipose tissues (ATs), where it
is thought to play an important role in fat mobilization. The purpose of the present work was
to study the effect of a physiological increase of HSL expression in vivo. Transgenic mice
were produced with a 21 kb human genomic fragment encompassing the exons encoding
the adipocyte form of HSL. hHSL mRNA was expressed at 3-fold higher levels than murine …
cholesteryl esters (CEs). The enzyme is highly expressed in adipose tissues (ATs), where it
is thought to play an important role in fat mobilization. The purpose of the present work was
to study the effect of a physiological increase of HSL expression in vivo. Transgenic mice
were produced with a 21 kb human genomic fragment encompassing the exons encoding
the adipocyte form of HSL. hHSL mRNA was expressed at 3-fold higher levels than murine …