[HTML][HTML] Adipose-specific lipoprotein lipase deficiency more profoundly affects brown than white fat biology
I Garcia-Arcos, Y Hiyama, K Drosatos… - Journal of Biological …, 2013 - ASBMB
Adipose fat storage is thought to require uptake of circulating triglyceride (TG)-derived fatty
acids via lipoprotein lipase (LpL). To determine how LpL affects the biology of adipose
tissue, we created adipose-specific LpL knock-out (ATLO) mice, and we compared them with
whole body LpL knock-out mice rescued with muscle LpL expression (MCK/L0) and wild
type (WT) mice. ATLO LpL mRNA and activity were reduced, respectively, 75 and 70% in
gonadal adipose tissue (GAT), 90 and 80% in subcutaneous tissue, and 84 and 85% in …
acids via lipoprotein lipase (LpL). To determine how LpL affects the biology of adipose
tissue, we created adipose-specific LpL knock-out (ATLO) mice, and we compared them with
whole body LpL knock-out mice rescued with muscle LpL expression (MCK/L0) and wild
type (WT) mice. ATLO LpL mRNA and activity were reduced, respectively, 75 and 70% in
gonadal adipose tissue (GAT), 90 and 80% in subcutaneous tissue, and 84 and 85% in …