[HTML][HTML] ANGPTL3 decreases very low density lipoprotein triglyceride clearance by inhibition of lipoprotein lipase
T Shimizugawa, M Ono, M Shimamura… - Journal of Biological …, 2002 - ASBMB
KK/San is a mutant mouse strain established in our laboratory from KK obese mice. KK/San
mice show low plasma lipid levels compared with wild-type KK mice despite showing signs
of hyperglycemia and hyperinsulinemia. Recently, we identified a mutation in the gene
encoding angiopoietin-like protein 3 (Angptl3) in KK/San mice, and injection of
adenoviruses encodingAngptl3 or recombinant ANGPTL3 protein to mutant KK/San mice
raised plasma lipid levels. To elucidate the regulatory mechanism of ANGPTL3 on lipid …
mice show low plasma lipid levels compared with wild-type KK mice despite showing signs
of hyperglycemia and hyperinsulinemia. Recently, we identified a mutation in the gene
encoding angiopoietin-like protein 3 (Angptl3) in KK/San mice, and injection of
adenoviruses encodingAngptl3 or recombinant ANGPTL3 protein to mutant KK/San mice
raised plasma lipid levels. To elucidate the regulatory mechanism of ANGPTL3 on lipid …