[HTML][HTML] The obesity paradox in community-acquired bacterial pneumonia
VF Corrales-Medina, J Valayam, JA Serpa… - International Journal of …, 2011 - Elsevier
VF Corrales-Medina, J Valayam, JA Serpa, AM Rueda, DM Musher
International Journal of Infectious Diseases, 2011•ElsevierBACKGROUND: The impact of obesity on the outcome of pneumonia is uncertain.
METHODS: We retrospectively identified 266 hospitalized patients with proven
pneumococcal or Haemophilus community-acquired pneumonia who had at least one body
mass index (BMI, kg/m2) value documented in the 3 months before admission. Patients were
classified as underweight (BMI< 18.5), normal weight (BMI 18.5 to< 25), overweight (BMI 25
to< 30), or obese (BMI≥ 30). The association of absolute BMI values and BMI categories …
METHODS: We retrospectively identified 266 hospitalized patients with proven
pneumococcal or Haemophilus community-acquired pneumonia who had at least one body
mass index (BMI, kg/m2) value documented in the 3 months before admission. Patients were
classified as underweight (BMI< 18.5), normal weight (BMI 18.5 to< 25), overweight (BMI 25
to< 30), or obese (BMI≥ 30). The association of absolute BMI values and BMI categories …
BACKGROUND
The impact of obesity on the outcome of pneumonia is uncertain.
METHODS
We retrospectively identified 266 hospitalized patients with proven pneumococcal or Haemophilus community-acquired pneumonia who had at least one body mass index (BMI, kg/m2) value documented in the 3 months before admission. Patients were classified as underweight (BMI <18.5), normal weight (BMI 18.5 to <25), overweight (BMI 25 to <30), or obese (BMI ≥30). The association of absolute BMI values and BMI categories with the mortality at 30 days after admission for pneumonia was investigated.
RESULTS
Increasing BMI values were associated with reduced 30-day mortality, even after adjustment for significant covariates (odds ratio 0.88, confidence interval 0.81–0.96; p<0.01). There was a significant trend towards lower mortality in the overweight and obese (non-parametric trend, p=0.02).
CONCLUSIONS
Our data suggest that obesity may exert a protective effect against 30-day mortality from community-acquired bacterial pneumonia.
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