[PDF][PDF] Immunological goings-on in visceral adipose tissue

D Mathis - Cell metabolism, 2013 - cell.com
D Mathis
Cell metabolism, 2013cell.com
Chronic, low-grade inflammation of visceral adipose tissue, and systemically, is a critical link
between recent strikingly parallel rises in the incidence of obesity and type 2 diabetes.
Macrophages have been recognized for some time to be critical participants in obesity-
induced inflammation of adipose tissue. Of late, a score of other cell types of the innate and
adaptive arms of the immune system have been suggested to play a positive or negative
role in adipose tissue infiltrates. This piece reviews the existing data on these new …
Chronic, low-grade inflammation of visceral adipose tissue, and systemically, is a critical link between recent strikingly parallel rises in the incidence of obesity and type 2 diabetes. Macrophages have been recognized for some time to be critical participants in obesity-induced inflammation of adipose tissue. Of late, a score of other cell types of the innate and adaptive arms of the immune system have been suggested to play a positive or negative role in adipose tissue infiltrates. This piece reviews the existing data on these new participants; discusses experimental uncertainties, inconsistencies, and complexities; and puts forward a minimalist synthetic scheme.
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