Importance Infections due to Staphylococcus aureus are serious complications of
cardiothoracic surgery. A novel vaccine candidate (V710) containing the highly conserved S
aureus iron surface determinant B is immunogenic and generally well tolerated in
volunteers. Objective To evaluate the efficacy and safety of preoperative vaccination in
preventing serious postoperative S aureus infection in patients undergoing cardiothoracic
surgery. Design, Setting, and Participants Double-blind, randomized, event-driven trial …