Absence of the IL-7 receptor component Cdw127 indicates that γCexpression alone is insufficient for IL-7 to modulate human neutrophil responses
D Girard, AD Beaulieu - Clinical immunology and immunopathology, 1997 - Elsevier
It has been proposed that neutrophils are targets for interleukin-7 (IL-7) because this
cytokine was found to increase the number of murine immature neutrophilsin vivo. In
addition, some nonhuman myeloid cell lines were shown to express the IL-7 receptor (IL-
7R). Moreover, it was recently discovered that human neutrophils constitutively express the
common gamma chain (γc), known to be a component of not only IL-7R, but also IL-2R, IL-
4R, IL-9R, and IL-15R. Among these, we have recently observed that IL-4 and IL-15 are …
cytokine was found to increase the number of murine immature neutrophilsin vivo. In
addition, some nonhuman myeloid cell lines were shown to express the IL-7 receptor (IL-
7R). Moreover, it was recently discovered that human neutrophils constitutively express the
common gamma chain (γc), known to be a component of not only IL-7R, but also IL-2R, IL-
4R, IL-9R, and IL-15R. Among these, we have recently observed that IL-4 and IL-15 are …