Interleukin-7: physiological roles and mechanisms of action
R Hofmeister, AR Khaled, N Benbernou… - Cytokine & growth factor …, 1999 - Elsevier
Interleukin-7 (IL-7), a product of stromal cells, provides critical signals to lymphoid cells at
early stages in their development. Two types of cellular responses to IL-7 have been
identified in lymphoid progenitors:(1) a trophic effect and (2) an effect supporting V (D) J
recombination. The IL-7 receptor is comprised of two chains, IL-7Rα and γc. Following
receptor crosslinking, rapid activation of several classes of kinases occurs, including
members of the Janus and Src families and PI3-kinase. A number of transcription factors are …
early stages in their development. Two types of cellular responses to IL-7 have been
identified in lymphoid progenitors:(1) a trophic effect and (2) an effect supporting V (D) J
recombination. The IL-7 receptor is comprised of two chains, IL-7Rα and γc. Following
receptor crosslinking, rapid activation of several classes of kinases occurs, including
members of the Janus and Src families and PI3-kinase. A number of transcription factors are …