Rifaximin exerts beneficial effects independent of its ability to alter microbiota composition
DJ Kang, G Kakiyama, NS Betrapally… - Clinical and …, 2016 - journals.lww.com
OBJECTIVES: Rifaximin has clinical benefits in minimal hepatic encephalopathy (MHE) but
the mechanism of action is unclear. The antibiotic-dependent and-independent effects of
rifaximin need to be elucidated in the setting of MHE-associated microbiota. To assess the
action of rifaximin on intestinal barrier, inflammatory milieu and ammonia generation
independent of microbiota using rifaximin. METHODS: Four germ-free (GF) mice groups
were used (1) GF,(2) GF+ rifaximin,(3) Humanized with stools from an MHE patient, and (4) …
the mechanism of action is unclear. The antibiotic-dependent and-independent effects of
rifaximin need to be elucidated in the setting of MHE-associated microbiota. To assess the
action of rifaximin on intestinal barrier, inflammatory milieu and ammonia generation
independent of microbiota using rifaximin. METHODS: Four germ-free (GF) mice groups
were used (1) GF,(2) GF+ rifaximin,(3) Humanized with stools from an MHE patient, and (4) …