Electrophilic nitro-FAs (NO 2-FAs) promote adaptive and anti-inflammatory cell signaling
responses as a result of an electrophilic character that supports posttranslational protein
modifications. A unique pharmacokinetic profile is expected for NO 2-FAs because of an
ability to undergo reversible reactions including Michael addition with cysteine-containing
proteins and esterification into complex lipids. Herein, we report via quantitative whole-body
autoradiography analysis of rats gavaged with radiolabeled 10-nitro-[14 C] oleic acid …