Metabolic fibroblast growth factors (FGFs): mediators of energy homeostasis
KR Markan, MJ Potthoff - Seminars in cell & developmental biology, 2016 - Elsevier
Seminars in cell & developmental biology, 2016•Elsevier
The metabolic fibroblast growth factors (FGFs), FGF1, FGF15/19, and FGF21 differ from
classic FGFs in that they modulate energy homeostasis in response to fluctuating nutrient
availability. These unique mediators of metabolism regulate a number of physiological
processes which contribute to their potent pharmacological properties. Administration of
pharmacological doses of these FGFs causes weight loss, increases energy expenditure,
and improves carbohydrate and lipid metabolism in obese animal models. However, many …
classic FGFs in that they modulate energy homeostasis in response to fluctuating nutrient
availability. These unique mediators of metabolism regulate a number of physiological
processes which contribute to their potent pharmacological properties. Administration of
pharmacological doses of these FGFs causes weight loss, increases energy expenditure,
and improves carbohydrate and lipid metabolism in obese animal models. However, many …
Abstract
The metabolic fibroblast growth factors (FGFs), FGF1, FGF15/19, and FGF21 differ from classic FGFs in that they modulate energy homeostasis in response to fluctuating nutrient availability. These unique mediators of metabolism regulate a number of physiological processes which contribute to their potent pharmacological properties. Administration of pharmacological doses of these FGFs causes weight loss, increases energy expenditure, and improves carbohydrate and lipid metabolism in obese animal models. However, many questions remain regarding the precise molecular and physiological mechanisms governing the effects of individual metabolic FGFs. Here we review the metabolic actions of FGF1, FGF15/19, and FGF21 while providing insights into their pharmacological effects by examining known biological functions.
Elsevier