Genetic CD21 deficiency is associated with hypogammaglobulinemia
J Thiel, L Kimmig, U Salzer, M Grudzien… - Journal of allergy and …, 2012 - Elsevier
BACKGROUND: Complement receptor 2 (CR2/CD21) is part of the B-cell coreceptor and
expressed by mature B cells and follicular dendritic cells. CD21 is a receptor for C3d-
opsonized immune complexes and enhances antigen-specific B-cell responses.
OBJECTIVE: Genetic inactivation of the murine CR2 locus results in impaired humoral
immune responses. Here we report the first case of a genetic CD21 deficiency in human
subjects. METHODS: CD21 protein expression was analyzed by means of flow cytometry …
expressed by mature B cells and follicular dendritic cells. CD21 is a receptor for C3d-
opsonized immune complexes and enhances antigen-specific B-cell responses.
OBJECTIVE: Genetic inactivation of the murine CR2 locus results in impaired humoral
immune responses. Here we report the first case of a genetic CD21 deficiency in human
subjects. METHODS: CD21 protein expression was analyzed by means of flow cytometry …
