The sorting nexin 3 retromer pathway regulates the cell surface localization and activity of a Wnt-activated polycystin channel complex
S Feng, AJ Streets, V Nesin, U Tran, H Nie… - Journal of the …, 2017 - journals.lww.com
Autosomal dominant polycystic kidney disease (ADPKD) is caused by inactivating mutations
in PKD1 (85%) or PKD2 (15%). The ADPKD proteins encoded by these genes, polycystin-1
(PC1) and polycystin-2 (PC2), form a plasma membrane receptor–ion channel complex.
However, the mechanisms controlling the subcellular localization of PC1 and PC2 are
poorly understood. Here, we investigated the involvement of the retromer complex, an
ancient protein module initially discovered in yeast that regulates the retrieval, sorting, and …
in PKD1 (85%) or PKD2 (15%). The ADPKD proteins encoded by these genes, polycystin-1
(PC1) and polycystin-2 (PC2), form a plasma membrane receptor–ion channel complex.
However, the mechanisms controlling the subcellular localization of PC1 and PC2 are
poorly understood. Here, we investigated the involvement of the retromer complex, an
ancient protein module initially discovered in yeast that regulates the retrieval, sorting, and …