Pharmacologic or genetic manipulation of glutathione S-transferase P1–1 (GSTπ) influences cell proliferation pathways
JE Ruscoe, LA Rosario, T Wang, L Gaté… - The Journal of …, 2001 - Elsevier
ABSTARCT Glutathione S-transferase P1–1 (GSTπ) is an abundant and ubiquitously
expressed protein in normal and malignant mammalian tissues and possesses catalytic and
ligand binding properties. Our present data suggest that the protein contributes to the
regulation of cell proliferation. Mouse embryo fibroblasts (MEFs) isolated from mice with a
GSTP1–1 [glutathioneS-transferase P1–1 (isozyme in nonhepatic tissue)] null genotype
(GSTπ−/−) doubled their population in 26.2 h versus 33.6 h for the wild type (GSTπ+/+) …
expressed protein in normal and malignant mammalian tissues and possesses catalytic and
ligand binding properties. Our present data suggest that the protein contributes to the
regulation of cell proliferation. Mouse embryo fibroblasts (MEFs) isolated from mice with a
GSTP1–1 [glutathioneS-transferase P1–1 (isozyme in nonhepatic tissue)] null genotype
(GSTπ−/−) doubled their population in 26.2 h versus 33.6 h for the wild type (GSTπ+/+) …
