[HTML][HTML] Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3+ Treg cell function in the intestine
OJ Harrison, N Srinivasan, J Pott, C Schiering… - Mucosal …, 2015 - Elsevier
Elevated levels of interleukin-18 (IL-18) are found in many chronic inflammatory disorders,
including inflammatory bowel disease (IBD), and polymorphisms in the IL18R1–IL18RAP
locus are associated with IBD susceptibility. IL-18 is an IL-1 family cytokine that has been
proposed to promote barrier function in the intestine, but the effects of IL-18 on intestinal
CD4+ T cells are poorly understood. Here we demonstrate that IL-18R1 expression is
enhanced on both effector and regulatory CD4+ T cells in the intestinal lamina propria, with …
including inflammatory bowel disease (IBD), and polymorphisms in the IL18R1–IL18RAP
locus are associated with IBD susceptibility. IL-18 is an IL-1 family cytokine that has been
proposed to promote barrier function in the intestine, but the effects of IL-18 on intestinal
CD4+ T cells are poorly understood. Here we demonstrate that IL-18R1 expression is
enhanced on both effector and regulatory CD4+ T cells in the intestinal lamina propria, with …