We used expression microarrays to characterize the changes most specific for pure T cell–
mediated rejection (TCMR) compared to other diseases including antibody-mediated
rejection in 703 human kidney transplant biopsies, using a Discovery Set–Validation Set
approach. The expression of thousands of transcripts—fold change and association strength—
changed in a pattern that was highly conserved between the Discovery and Validation sets,
reflecting a hierarchy of T cell signaling, costimulation, antigen-presenting cell (APC) …