[HTML][HTML] Gene expression in biopsies of acute rejection and interstitial fibrosis/tubular atrophy reveals highly shared mechanisms that correlate with worse long‐term …

BD Modena, SM Kurian, LW Gaber, J Waalen… - American Journal of …, 2016 - Elsevier
Interstitial fibrosis and tubular atrophy (IFTA) is found in approximately 25% of 1‐year
biopsies posttransplant. It is known that IFTA correlates with decreased graft survival when
histological evidence of inflammation is present. Identifying the mechanistic etiology of IFTA
is important to understanding why long‐term graft survival has not changed as expected
despite improved immunosuppression and dramatically reduced rates of clinical acute
rejection (AR)(Services UDoHaH. http://www. ustransplant. org/annual_reports/current …