[HTML][HTML] A pathogenesis-based transcript signature in donor-specific antibody-positive kidney transplant patients with normal biopsies

PÓ Broin, N Hayde, Y Bao, B Ye, RB Calder… - Genomics data, 2014 - Elsevier
PÓ Broin, N Hayde, Y Bao, B Ye, RB Calder, G de Boccardo, M Lubetzky, M Ajaimy…
Genomics data, 2014Elsevier
Abstract Affymetrix Human Gene 1.0-ST arrays were used to assess the gene expression
profiles of kidney transplant patients who presented with donor-specific antibodies (DSAs)
but showed normal biopsy histopathology and did not develop antibody-mediated rejection
(AMR). Biopsy and whole-blood profiles for these DSA-positive, AMR-negative
(DSA+/AMR−) patients were compared to both DSA-positive, AMR-positive (DSA+/AMR+)
patients as well as DSA-negative (DSA−) controls. While individual gene expression …
Abstract
Affymetrix Human Gene 1.0-ST arrays were used to assess the gene expression profiles of kidney transplant patients who presented with donor-specific antibodies (DSAs) but showed normal biopsy histopathology and did not develop antibody-mediated rejection (AMR). Biopsy and whole-blood profiles for these DSA-positive, AMR-negative (DSA +/AMR−) patients were compared to both DSA-positive, AMR-positive (DSA +/AMR +) patients as well as DSA-negative (DSA −) controls. While individual gene expression changes across sample groups were relatively subtle, gene-set enrichment analysis using previously identified pathogenesis-based transcripts (PBTs) identified a clear molecular signature involving increased rejection-associated transcripts in AMR − patients. Results from this study have been published in Kidney International (Hayde et al., 2014 [1]) and the associated data have been deposited in the GEO archive and are accessible via the following link: http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE50084
Elsevier