[HTML][HTML] Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors
The members of the NR5A subfamily of nuclear receptors (NRs) are important regulators of
pluripotency, lipid and glucose homeostasis, and steroidogenesis. Liver receptor
homologue 1 (LRH-1; NR5A2) and steroidogenic factor 1 (SF-1; NR5A1) have therapeutic
potential for the treatment of metabolic and neoplastic disease; however, a poor
understanding of their ligand regulation has hampered the pursuit of these proteins as
pharmaceutical targets. In this study, we dissect how sequence variation among LRH-1 …
pluripotency, lipid and glucose homeostasis, and steroidogenesis. Liver receptor
homologue 1 (LRH-1; NR5A2) and steroidogenic factor 1 (SF-1; NR5A1) have therapeutic
potential for the treatment of metabolic and neoplastic disease; however, a poor
understanding of their ligand regulation has hampered the pursuit of these proteins as
pharmaceutical targets. In this study, we dissect how sequence variation among LRH-1 …