[HTML][HTML] ABCG1 redistributes cell cholesterol to domains removable by high density lipoprotein but not by lipid-depleted apolipoproteins
AM Vaughan, JF Oram - Journal of Biological Chemistry, 2005 - ASBMB
ATP binding cassette transporter G1 (ABCG1) mediates the transport of cholesterol from
cells to high density lipoprotein (HDL) but not to lipid-depleted apolipoprotein AI. Here we
show that human ABCG1 overexpressed in baby hamster kidney cells in the absence of
lipoproteins traffics to the plasma membrane and redistributes membrane cholesterol to cell-
surface domains accessible to treatment with the enzyme cholesterol oxidase. Cholesterol
removed by HDL was largely derived from these domains in ABCG1 transfectants but not in …
cells to high density lipoprotein (HDL) but not to lipid-depleted apolipoprotein AI. Here we
show that human ABCG1 overexpressed in baby hamster kidney cells in the absence of
lipoproteins traffics to the plasma membrane and redistributes membrane cholesterol to cell-
surface domains accessible to treatment with the enzyme cholesterol oxidase. Cholesterol
removed by HDL was largely derived from these domains in ABCG1 transfectants but not in …